Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 207, Issue 2, Pages 508-511Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2009.10.020
Keywords
Reward; Addiction; Reinforcement; Cognition
Categories
Funding
- NIAAA (intramural Research Program, LNI)
- NIH IRTA program
- Stony Brook URECA program
- BNL SULI program
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In this study we examined the genetic contribution of the D4R in food and cocaine self-administration using D4R mice. Mice were examined for operant responding to food pellets or intravenous cocaine. Compared to wild-type mice (D4R(+/+)), both heterozygous (D4R(+/-)) and knockout (D4R(-/-)) mice showed no difference in responding for food or cocaine. Our findings suggest that the D4R is not directly involved in mediating operant response behaviors for food or cocaine. Published by Elsevier B.V.
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