Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 198, Issue 2, Pages 472-476Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2008.11.036
Keywords
Antidepressant; Neurosteroids; Sigma-1; Forced swim
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Funding
- National Institutes of Health [5K99AA016731-02, 1T32NS061847-01A2]
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Activation of sigma-1 receptors (Sig-1R) reportedly has antidepressant-like action. Limited data suggest that Sig-1Rs also modulate anxiety-related behaviors. The present experiments measured depressive-like, anxiety-like and motor behavior in Sig-1R knockout mice and their wildtype littermates. Sig-1R knockout mutants showed increased immobility in the forced swimming test, a depressive-like phenotype, but normal anxiety-like behavior in the elevated plus-maze and light/dark box tests and normal locomotor activity. The results further suggest that Sig-1Rs inversely modulate depressive-like behavior. (C) 2008 Elsevier B.V. All rights reserved.
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