Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 198, Issue 1, Pages 252-257Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2008.11.008
Keywords
Nucleus accumbens; Acetylcholine; Muscarinic receptors; Feeding; Food intake; Scopolamine; AFDX-116; Oxotremorine sesquifumarate
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Funding
- Wake Forest University Summer Undergraduate Fellowship
- Wake Forest University Department of Psychology
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Separate groups of food-deprived rats were given 2 h access to food after receiving bilateral nucleus accumbens infusions of the muscarinic antagonist scopolamine methyl bromide (at 0, 1.0, and 10.0 mu g/side), the M2-preferring agonist oxotremorine sesquifumarate (Oxo-S; at 0, 1.0. or 10.0 mu g/side) or the M2 antagonist AFDX-116 (at 0, 0.2, or 1.0 mu g/side). Injections of scopolamine or Oxo-S, but not AFDX-116, reduced food consumption across the 2 h. These experiments confirm a critical role for Acb acetylcholine in promoting food ingestion, and suggest that decreased acetylcholine tone at post-synaptic muscarinic receptors disrupts normal consummatory behavior. (C) 2008 Elsevier B.V. All rights reserved.
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