Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 204, Issue 2, Pages 295-305Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2008.11.039
Keywords
Schizophrenia; Neurodevelopment; Dopamine; Interneurons
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Funding
- Rosalind Franklin University/Chicago Medical School Start-up funds
- NIDA [K08-DA019850]
- National Institutes of Health
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Traditionally, animal models of schizophrenia were predominantly pharmacological constructs focused on phenomena linked to dopamine and glutamate neurotransmitter systems, and were created by direct perturbations of these systems. A number of developmental models were subsequently generated that allowed testing of hypotheses about the origin of the disease, mimicked a wider array of clinical and neurobiological features of schizophrenia, and opened new avenues for developing novel treatment strategies. The most thoroughly characterized (similar to 100 primary research articles) is the neonatal ventral hippocampal lesion (NVHL) model, which is the subject of this review. We highlight its advantages and limitations, and how it may offer clues about the extent to which positive, negative, cognitive, and other aspects of schizophrenia, including addiction vulnerability, represent inter-related pathophysiological mechanisms. (C) 2008 Elsevier B.V. All rights reserved.
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