Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 197, Issue 1, Pages 225-229Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2008.08.002
Keywords
Accumbens; Muscarinic; Opioid; Feeding; Scopolamine; Eating; Acetylcholine
Categories
Funding
- National Institute on Drug Abuse [1101 DA009311, R37 DA004788, F31 DA023775-01AI]
- National Institute of Mental Health [1101 MH074723]
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Intra-nucleus accumbens (Acb) infusion of cholinergic muscarinic antagonist, scopolamine (10 mu g/0.5 mu l), markedly reduced fat intake elicited by intra-Acb treatment of the mu-opioid receptor agonist, DAMGO, with 30 min and 4 h pretreatment intervals. Intra-Acb scopolamine infusions also reduced food intake in food-deprived rats, but not water intake in water-deprived rats. Hence, Acb muscarinic manipulations exhibit some specificity for feeding, perhaps via interactions with the striatal opioid system. (c) 2008 Elsevier B.V. All rights reserved.
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