Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 205, Issue 1, Pages 319-321Publisher
ELSEVIER
DOI: 10.1016/j.bbr.2009.07.008
Keywords
Stress; Animal model; Maternal separation; Arachidonic acid; Depression; Gas chromatography
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Funding
- Science Foundation of Ireland (SFI)
- Glaxosmithkline (GSK)
- Wellcome trust
- Health Research Board (HRB)
- Teagasc Walsh Fellowship
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The rat maternal separation paradigm can be used to examine the biological consequences of early-life stress. Immunomodulatory polyunsaturated fatty acids (PUFAs) have recently attracted attention in the study of stress-related disorders. We established the plasma PUFA profile of maternally separated rodents compared to controls. Our results identify a proinflammatory PUFA profile as a persistent consequence of early-life stress and suggest new avenues of investigation in stress-related disorders. (C) 2009 Elsevier B.V. All rights reserved.
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