Journal
CURRENT OPINION IN RHEUMATOLOGY
Volume 13, Issue 5, Pages 377-382Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002281-200109000-00006
Keywords
-
Categories
Ask authors/readers for more resources
Antiphospholipid antibodies are the marker for antiphospholipid syndrome. There is evidence that these autoantibodies lead to both thrombotic diathesis and obstetrical manifestations. Besides the known interaction with soluble coagulation factors, in vitro and in vivo experimental models and studies in humans recently have shown the ability of anti phospholipid antibodies to modulate functions of cells involved in coagulation homeostasis. These findings support a new hypothesis to explain the paradox of the prolongation of coagulation assays in vitro and the association with thrombophilic diathesis in vivo. Obstetrical manifestations have been linked to a direct antibody effect on the trophoblast leading to defective placentation that is not necessarily associated with thrombotic phenomena. Phospholipid binding proteins such as beta (2)-glycoprotein I appear to behave as a bridge between circulating antiphospholipid antibodies and cellular targets. (C) 2001 Lippincott Williams & Wilkins, Inc.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available