Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 202, Issue 1, Pages 114-121Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2009.03.028
Keywords
Social isolation; Methylphenidate; Clozapine; Fluoxetine; Aggressive behavior; Anxiety-like behavior; Social interaction
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Funding
- JSPS [19390062]
- Ministry of Education, Culture, Sports, Science and Technology of Japan
- Academic Frontier Project for Private Universities
- MEXT, 2007-2011
- Ministry of Health, Labour and Welfare
- Takeda Science Foundation
- AstraZeneca Research
- JST, CREST
- Grants-in-Aid for Scientific Research [19390062] Funding Source: KAKEN
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Social isolation (SI) rearing in rodents causes a variety of behavioral changes, including hyperlocomotion, anxiety, impulsivity, aggression, and learning and memory deficits. These behavioral abnormalities in rodents may be related to the symptoms in patients with neuro psychiatric disorders, such as attention-deficit hyperactivity disorder, obsessive-compulsive disorder, autism, schizophrenia and depression. In this study, we examined the effect of long-term SI rearing after weaning on emotional behaviors and cognitive function in mice. Furthermore, the effects of methylphenidate (MPH), clozapine (CLZ)and fluoxetine (FIX) on SI-induced behavioral changes were examined to measure the predictive validity of SI-reared mice as an animal model for these neuropsychiatric disorders. MPH improved SI-induced anxiety-like behavior in the elevated-plus maze test, but had no effect on aggressive behavior. In contrast, CLZ ameliorated aggressive behavior, but not anxiety-like behavior in SI-reared mice. Repeated FIX treatment prevented SI-induced aggressive behavior and social interaction deficits. These findings suggest that SI-induced behavioral abnormality is a psychobehavioral complex relevant to various clinical symptoms observed in neuro psychiatric disorders and that SI-reared mice are a useful animal model to study the pathophysiology/pathogenesis of these diseases. (c) 2009 Elsevier B.V. All rights reserved.
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