Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 193, Issue 2, Pages 315-319Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2008.06.016
Keywords
Sandhoff disease; mouse model; novel object recognition test; rotarod; motor coordination; balance beam; open field; memory
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Funding
- the Lysosomal Storage Disease Research Consortium
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Mouse models of lysosomal storage diseases, including Sandhoff disease, are frequently employed to test therapies directed at the central nervous system. We backbred such mice and conducted a behavioral test battery which included sensorimotor and cognitive assessments. This is the first report of short-term memory deficits in a murine model of Sandhoff disease. We also document early onset of motor deficits using the balance beam test. (C) 2008 Elsevier B.V. All rights reserved.
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