Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 186, Issue 2, Pages 191-196Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2007.08.008
Keywords
social recognition memory; mice; amino acids; autoradiography; olfactory
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We investigated the effects of anisomycin (ANI) treatment (150mg/kg s.c.) during late stages of memory consolidation in a juvenile recognition task in mice. ANI treatment blocked 24 h recognition memory if administered 9 h, 12 h or 15 h after learning. As shown by a significantly reduced incorporation of radioactively labelled amino acids into newly synthesized proteins, translational arrest by ANI treatment lasted for 3-4 h, thus covering the complete time period between 9 h and 18 h after memory acquisition. Together with previous findings [Richter K, Wolf G, Engelmann M. Social recognition memory requires two stages of protein synthesis in mice. Learn Mem 2005; 12(4):407-13], our data suggest two distinct stages of protein synthesis to occur during the first 24 h after learning: an early, relatively short-stage, starting immediately after learning and lasting for approximately 3 h, and a second stage starting 6 h after learning lasting for approximately 12 h. This is the first report of such a long-lasting protein synthesis-dependent second consolidation phase in mice and suggests that long-term consolidation of juvenile recognition memory comprises multiple waves of protein synthesis and complex cascades of inter- and intra-cellular signaling processes. (C) 2007 Elsevier B.V. All rights reserved.
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