Journal
TRENDS IN GENETICS
Volume 17, Issue 9, Pages 520-527Publisher
ELSEVIER SCIENCE LONDON
DOI: 10.1016/S0168-9525(01)02366-6
Keywords
-
Categories
Ask authors/readers for more resources
CTCF is an evolutionarily conserved zinc finger (ZF) phosphoprotein that binds through combinatorial use of its 11 ZFs to similar to 50 bp target sites that have remarkable sequence variation. Formation of different CTCF-DNA complexes, some of which are methylation-sensitive, results in distinct functions, including gene activation, repression, silencing and chromatin insulation. Disrupting the spectrum of target specificities by ZF mutations or by abnormal selective methylation of targets is associated with cancer, CTCF emerges, therefore, as a central player in networks linking expression domains with epigenetics and cell growth regulation.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available