Journal
INTERNATIONAL ARCHIVES OF OCCUPATIONAL AND ENVIRONMENTAL HEALTH
Volume 74, Issue 7, Pages 519-522Publisher
SPRINGER-VERLAG
DOI: 10.1007/s004200100252
Keywords
cytochrome P4502E1; genetic polymorphism; genotype; phenotype; N,N-dimethylformamide
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Objectives: This study examined whether consideration of the *1C/*1D CY-P2E1 insertion polymorphism is important for interpreting the biological monitoring of exposure to NN-dimethylformamide (DMF) in Japanese workers. Methods: The insertion genotype, airborne DMF exposure on the last day of a work week, and NMF in urine sampled just after the last workshift of the week were determined in 44 male and female Japanese workers. Results and conclusions. The allelic frequency of this CYP2E1 polymorphism was 0.261 in this Japanese population of workers. The CYP2E1 insertion polymorphism did not contribute to NMF levels even after consideration of BMI or alcohol intake. The results indicate that CYP2E1 insertion polymorphism does not appear to be an important determinant for the interpretation of biological exposure to DMF by the measurement of urinary NMF.
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