Journal
BEST PRACTICE & RESEARCH CLINICAL HAEMATOLOGY
Volume 14, Issue 3, Pages 479-495Publisher
ELSEVIER SCI LTD
DOI: 10.1053/beha.2001.0151
Keywords
myelodysplastic syndromes; prognosis; cytogenetic analysis; chromosome aberrations; chromosome mapping; oncogenes
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The myelodysplastic syndromes are a collection of five clinico-pathological entities with a wide spectrum of clinical behaviours and survival outcomes. Cytogenetic analysis has been instrumental in refining the prognosis, predicting the likelihood of progression to acute myeloid leukaemia and median survival, and in establishing clonality of these diseases. This review highlights the most frequent abnormalities and summarizes their clinical and genetic features.
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