Journal
MOLECULAR IMMUNOLOGY
Volume 38, Issue 5, Pages 359-364Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0161-5890(01)00072-4
Keywords
CD3 epsilon; evolution; Macropus eugenii; cDNA cloning; marsupial
Categories
Ask authors/readers for more resources
The cDNA encoding the epsilon chain of the tammar wallaby CD3 complex (CD3 epsilon;) was isolated by PCR. This is the first CD3 component to be cloned in a marsupial. The tammar wallaby cDNA coding region was 61.7 and 63.0%, identical to the human and mouse cDNA coding sequences, respectively. Similarly, the predicted amino acid sequence was 56.5 and 52.9% identical to the human and mouse sequences. When compared with other known CD3 epsilon peptide sequences. the most conserved region of the tammar wallaby CD3 epsilon chain peptide was the cytoplasmic domain and the least conserved was the extracellular portion. Phylogenetic reconstruction based on the deduced amino acid sequence placed the tammar wallaby sequence in its expected position outside of all the eutherian mammals. (C) 2001 Elsevier Science Ltd. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available