Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 188, Issue 1, Pages 233-237Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2007.09.015
Keywords
Ts65Dn; object recognition; medial temporal lobe; Down syndrome
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Funding
- NINDS NIH HHS [P01 NS053862, P01 NS053862-05, R01 NS039471, R01 NS039471-09] Funding Source: Medline
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Ts65Dn mice, like individuals with Down syndrome (DS), demonstrate a functional dissociation between explicit and implicit forms of memory, showing selective impairment in explicit or declarative learning tasks. Here, we explored Ts65Dn explicit memory deficits further by evaluating the ability of these mice to assimilate the temporal and spatial contexts under which previously novel objects had been encountered. We found that Ts65Dn mice could in fact form contextual representations of objects over the course of a few hours, contrary to their inability to discriminate object novelty over a more prolonged period of 24 It. These results suggest that Ts65Dn mice might have particular difficulties in declarative tasks requiring long-term memory, presenting an especially important putative therapeutic target for pre-clinical and clinical DS research. Published by Elsevier B.V.
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