Journal
BEHAVIOURAL BRAIN RESEARCH
Volume 189, Issue 2, Pages 317-324Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.bbr.2008.01.020
Keywords
Huntington's disease; Hdh(Q92) mouse model; 9-hole box; motor learning; implicit learning; operant tests
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Funding
- Biotechnology and Biological Sciences Research Council Funding Source: Medline
- Medical Research Council [G0500794] Funding Source: Medline
- Medical Research Council [G0500794] Funding Source: researchfish
- MRC [G0500794] Funding Source: UKRI
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A range of transgenic and knock-in mouse models of Huntington's disease have been created since identification in 1993 of the disease mutation in the HD gene. Knock-in models that express the full-length mutant protein tend to exhibit less severe behavioural deficits than transgenic models and so require more sensitive tasks in order to reveal impairments. To achieve this, we therefore used a Serial Implicit Learning Task (SILT), which measures serial reaction times to visual stimuli, requiring detection and responding in both predictable and unpredictable locations in the 9-hole operant chamber. We have previously reported that knock-in Hdh(Q92/Q92) mice exhibit a modest impairment in learning the SILT tasks at 4 months of age, prior to the formation of overt neuronal nuclear inclusions. In the present study we have explored the time course of the development of impairments from 5 to 14 months of age. The deficit previously found in accuracy and reaction time was present at all ages examined in these Hdh(Q92/Q92) mice; the deficit was not progressive, and did not correlate with the evolution of neuronal nuclear inclusions. (C) 2008 Elsevier B.V All rights reserved.
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