Journal
AMERICAN JOURNAL OF OBSTETRICS AND GYNECOLOGY
Volume 185, Issue 3, Pages 572-578Publisher
MOSBY-ELSEVIER
DOI: 10.1067/mob.2001.116754
Keywords
preeclampsia; oxidant stress; lipid peroxidation; isoprostane; pregnancy
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Funding
- NHLBI NIH HHS [HL 57847] Funding Source: Medline
- NICHD NIH HHS [N01-HD-2-3154, N01-HD-1-3126, N01-HD-1-3121, N01-HD-1-3125, N01-HD-5-3246, N01-HD-1-3124, N01-HD-1-3122, N01-HD-1-3123] Funding Source: Medline
- NIDDK NIH HHS [DK 44730] Funding Source: Medline
- PHS HHS [NIH 639302] Funding Source: Medline
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OBJECTIVE: This study was undertaken to address the role of oxidative stress in preeclampsia. STUDY DESIGN: We measured urinary 8,12-iso-iPF(2 alpha)-VI, a chemically stable, free-radical catalyzed product, in a case control study of severe preeclampsia nested within the trial of Calcium for Preeclampsia Prevention. Cases included 29 women who developed severe preeclampsia and from whom urine had been obtained 10 to 20 weeks before the diagnosis of preeclampsia, 3 to 9 weeks before, and 1 day before through delivery. Controls did not develop hypertension or proteinuria and were matched to cases by center, gestational age at each of 3 corresponding urine collections, and date of enrollment. RESULTS. Urinary 8,12-iso-iPF2 alpha -VI did not differ significantly between cases and controls before or at diagnosis of preeclampsia, nor did it vary with gestational age. CONCLUSIONS: These results call into question the importance of oxidative stress in the disease and the biochemical rationale for clinical trials of antioxidants to prevent and treat preeclampsia.
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