Journal
MECHANISMS OF DEVELOPMENT
Volume 107, Issue 1-2, Pages 69-82Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0925-4773(01)00452-X
Keywords
hair follicle; Wnt; Sonic hedgehog; mouse; skin; signaling; epidermis; dermis; dermal condensate; dermal papilla; outer root sheath; inner root sheath; gene expression; morphogenesis; basal cell carcinoma; placode; hair shaft; anagen; telogen; catagen; hair growth cycle
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Mutations in WNT effector genes perturb hair follicle morphogenesis, suggesting key roles for WNT proteins in this process. We show that expression of Wnts 10b and 10a is upregulated in placodes at the onset of follicle morphogenesis and in postnatal hair follicles beginning a new cycle of hair growth. The expression of additional Wnt genes is observed in follicles at later stages of differentiation. Among these, we find that Wnt5a is expressed in the developing dermal condensate of wild type but not Sonic hedgehog (Shh)-null embryos, indicating that Wnt5a is a target of SHH in hair follicle morphogenesis. These results identify candidates for several key follicular signals and suggest that WNT and SHH signaling pathways interact to regulate hair follicle morphogenesis. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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