Journal
IMMUNITY
Volume 15, Issue 3, Pages 435-443Publisher
CELL PRESS
DOI: 10.1016/S1074-7613(01)00196-0
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Funding
- NCI NIH HHS [CA 69031] Funding Source: Medline
- NIAMS NIH HHS [AR 37070] Funding Source: Medline
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The Nba2 locus is a major genetic contribution to disease susceptibility in the (NZB X NZW)F-1 mouse model of systemic lupus. We generated C57BL/6 mice congenic for this NZB locus, and these mice produced antinuclear autoantibodies characteristic of lupus. F-1 offspring of congenic and NZW mice developed high autoantibody levels and severe lupus nephritis similar to (NZB X NZW)F1 mice. Expression profiling with oligonucleotide microarrays revealed only two differentially expressed genes, interferon-inducible genes Ifi202 and Ifi203, in congenic versus control mice, and both were within the Nba2 interval. Quantitative PCR localized increased Ifi202 expression to splenic B cells and non-T/non-B cells. These results, together with analyses of promoter region polymorphisms, strain distribution of expression, and effects on cell proliferation and apoptosis, implicate Ifi202 as a candidate gene for lupus.
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