Journal
ENDOCRINE-RELATED CANCER
Volume 8, Issue 3, Pages 197-209Publisher
SOC ENDOCRINOLOGY
DOI: 10.1677/erc.0.0080197
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The IGF system components have been implicated in breast cancer progression. IGF-l and IGF-II are mitogenic and anti-apoptotic peptides that influence the proliferation of various cell types including normal and transformed breast epithelial cells. The IGF system is a key growth regulatory pathway in breast cancer. As various components of the IGF system have been directly or indirectly implicated in breast cancer, it is essential to gain a better understanding of these in order to develop more specific therapeutic strategies for treating breast cancer.
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