Journal
PAIN MEDICINE
Volume 2, Issue 3, Pages 208-215Publisher
OXFORD UNIV PRESS
DOI: 10.1046/j.1526-4637.2001.01030.x
Keywords
FMS; pain; sensitization; therapy
Categories
Ask authors/readers for more resources
Objective. To review die pathophysiology of fibromyalgia syndrome. Design. Review of the literature available on Medline (1965-2001). Results. Fibromyalgia syndrome is a chronic pain syndrome that predominantly afflicts, women. It is characterized by widespread pain, insomnia, fatigue, and the presence of multiple tender points. Despite intensifying research, the etiology of fibromyalgia has remained unclear. Importantly, neither infections, trauma, nor psychiatric abnormalities consistently precede the onset of pain in patients with this syndrome. There is, however, mounting evidence for central pain processing abnormalities in almost all fibromyalgia patients. These anomalies include hyperalgesia, allodynia, abnormal temporal summation of second pain, neuroendocrine abnormalities, and abnormal activation of pain-related brain regions. Conclusions. Multiple abnormal findings in fibromyalgia patients strongly indicate a neuropathic. pain syndrome, reminiscent of complex regional pain syndrome or postherpetic neuralgia. In addition, fibromyalgia syndrome seems to share similar characteristics with these neuropathic pain syndromes,. including ineffective response to many analgesics.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available