4.4 Article

Escherichia coli cytotoxic necrotizing factor and Pasteurella multocida toxin induce focal adhesion kinase autophosphorylation and Src association

Journal

INFECTION AND IMMUNITY
Volume 69, Issue 9, Pages 5931-5935

Publisher

AMER SOC MICROBIOLOGY
DOI: 10.1128/IAI.69.9.5931-5935.2001

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Funding

  1. NIDDK NIH HHS [U24 DK059630, DK 59630] Funding Source: Medline

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Cytotoxic necrotizing factor 1 and Pasteurella multocida toxin induced dose- and time-dependent increases in focal adhesion kinase (FAK) Tyr(397) phosphorylation in Swiss 3T3 cells. FAK autophosphorylation was sensitive to inhibitors of p160/ROCK and coincided with the formation of stable complexes between FAK and Src family members.

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