Journal
AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY
Volume 46, Issue 3, Pages 242-244Publisher
MUNKSGAARD INT PUBL LTD
DOI: 10.1034/j.1600-0897.2001.d01-8.x
Keywords
Anti-phosphatidylserine/prothrombin antibody; anti-phospholipid syndrome; anti-pro thrombin antibody; recurrent miscarriage
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OBJECTIVE: To determine whether the presence of anti-phosphatidylserine/ prothrombin antibodies (anti-PS/PT) can be a major factor in otherwise Unexplained recurrent miscarriages. PATIENTS AND METHODS: Eighty-one consecutive patients with history of 2 or more recurrent miscarriages were studied. Patients with history of overt thrombotic events were not included. Patients were examined for plausible causes of miscarriages, and titer of IgG, I-M and IgA anti-PS/PT were measured by enzyme-linked immunosorbent assay (ELISA). RESULTS: Thirty-five patients had one or more plausible causes of recurrent miscarriages, including 12 positive for well-established anti-phospholipid antibodies, such as anti-beta2-glycoprotein I. None of the patients included in this study was found to be positive for anti-PS/PT. CONCLUSION: Detection of anti-PS/PT in addition to other anti-phospholipid antibodies does not seem to aid in the evaluation of patients with unexplained recurrent miscarriages.
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