Journal
BEHAVIORAL NEUROSCIENCE
Volume 123, Issue 1, Pages 125-136Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0013734
Keywords
hemispheric asymmetry; basal ganglia; parietal lobe; visual spatial; Parkinson's disease
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Funding
- National Institute on Aging (NIA) [T32AGO0220]
- Signia Xi
- Department of Psychology, Boston University
- National Research service [U.32-AGO05914]
- National Institute of Mental Health [MH66213]
- National Institute of Neurological Disordeis and Stroke [NS052914]
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The role of corticostriatal circuits in hierarchical pattern perception was examined in Parkinson's disease. The hypothesis was tested that patients with right-side onset of motor symptoms (RPD, left hemisphere dysfunction) would be impaired at local level processing because the left posterior temporoparietal junction (TP) emphasizes processing of local information. By contrast, left-side onset patients (LPD; right hemisphere dysfunction) would show impaired global processing because right TP emphasizes global processing, Participants identified targets at local or global levels without and with attention biased toward those levels. Despite normal attentional control between levels, LPD patients showed a single dissociation, demonstrating abnormal global level processing tinder all conditions, whereas RPD patients showed abnormal local level processing mainly when attention was biased toward the local level. These findings link side of motor symptom onset to visuospatial cognitive abilities that depend upon the contralateral TP, highlighting that side of onset can predict visuospatial impairments, and provide evidence that an inferior parietal-basal ganglia pathway involving the caudate head and the hemi-spherically asymmetrical TP region is necessary for hierarchical pattern perception.
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