Journal
BEHAVIORAL NEUROSCIENCE
Volume 123, Issue 2, Pages 242-251Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0014625
Keywords
choice behavior; T-maze; amphetamine; haloperidol; SCH-23390
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Funding
- National Center for Research Resources [P20 RR16481]
- National Institute of Mental Health [R15 MH076788]
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Previous research has implicated dopamine as a modulating factor in choice behavior based on effort. The purpose of the present study was to determine the individual contribution of different dopamine receptors to effort-based decision making in rats. Rats were trained in a T-maze to choose a large-reward arm that contained 8 pellets of food over a small-reward arm that contained 2 pellets of food. The rats then were trained to climb progressively higher barriers to obtain the food from the large-reward arm. Using a discounting procedure on each test day, it was found that rats were more likely to choose the small-reward arm after treatment with the D(1) antagonist, SCH-23390, or the D(2) antagonist, haloperidol. The dopamine agonist, D-amphetamine, biased the rats toward choosing the large-reward arm and blunted the effects of SCH-23390 or haloperidol. Treatment with the D(3) receptor antagonist, U99194, or the D(3) receptor agonist, 7-OH-DPAT, did not alter choice behavior. These data indicate that D(1) and D(2) receptors are required for decisions based on effort.
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