Journal
BEHAVIORAL NEUROSCIENCE
Volume 123, Issue 1, Pages 115-124Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/a0013829
Keywords
temporal lobe; recognition; rat; perirhinal cortex; memory
Categories
Funding
- Wellcome Trust.
- Medical Research Council [G9724886] Funding Source: researchfish
- MRC [G9724886] Funding Source: UKRI
Ask authors/readers for more resources
The present study examines 2 factors that might moderate the object-recognition deficit seen after perirhinal cortex damage. Object recognition by normal rats was improved by extending (from 4 to 8 min) the sample period during which an object was first explored. Furthermore, there was a significant positive correlation between time spent in close exploration of the sample object and degree of successful novelty discrimination. In contrast, rats with perirhinal cortex lesions failed to benefit from increased close exploration and did not discriminate the novel object after even the longest sample period. Nevertheless, the lesions did not disrupt habituation across repeated exposure to the same object. The second factor was extent of perirhinal cortex damage. A significant correlation was found between total perirhinal cortex loss and degree of recognition impairment. Within the perirhinal cortex, only damage to the caudal perirhinal cortex correlated significantly with recognition memory deficits. This study highlights the critical importance of the perirhinal cortex within the temporal lobe for recognition memory and shows that the lesion-induced deficit occurs despite seemingly normal levels of close object exploration.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available