Journal
BEHAVIORAL NEUROSCIENCE
Volume 122, Issue 2, Pages 483-489Publisher
AMER PSYCHOLOGICAL ASSOC
DOI: 10.1037/0735-7044.122.2.483
Keywords
sociability; affiliative; anxiety; reward; cognition; genetic
Categories
Funding
- NATIONAL INSTITUTE OF MENTAL HEALTH [R01MH080718, K08MH068586] Funding Source: NIH RePORTER
- NIMH NIH HHS [K08MH068586, R01MH080718] Funding Source: Medline
Ask authors/readers for more resources
Individuals with fragile X syndrome (FXS) show varying degrees of social behavior disturbances, from social anxiety to autism. This variability of social behavior phenotypes in FXS is likely to be due to interactions of Fmr1 with other gene variants and environmental factors during brain development, although very little is known about the specific genetic and neural mechanisms involved. The Fmr1 knockout mouse is an important experimental resource for elucidating the neural mechanisms of social anxiety, social reward, and social cognition. However, studies of social behavior phenotypes in the Fmr1 knockout mouse are still in early stages. C. H. McNaughton et al. (2008) provide important new information on these phenotypes in the Fmr1 knockout mouse through their use of novel, detailed behavioral analysis to identify signs of increased social anxiety and social cognition deficits. Their significant refinements in measurement of social behavior phenotypes will help to advance future efforts to elucidate the genetic and neural mechanisms underlying social behavior disturbances in FXS and autism.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available