Journal
MOLECULAR AND CELLULAR BIOLOGY
Volume 21, Issue 17, Pages 5889-5898Publisher
AMER SOC MICROBIOLOGY
DOI: 10.1128/MCB.21.17.5889-5898.2001
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Cellular aging is accompanied by alterations in gene expression patterns. Here, using two models of replicative senescence, we describe the influence of the RNA-binding protein HuR in regulating the expression of several genes whose expression decreases during senescence. We demonstrate that HuR levels, HuR binding to target mRNAs encoding proliferative genes, and the half-lives of such mRNAs are lower in senescent cells. Importantly, overexpression of HuR in senescent cells restored a younger phenotype, while a reduction in HuR expression accentuated the senescent phenotype. Our studies highlight a critical role for HuR during the process of replicative senescence.
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