Journal
BIOTECHNOLOGY LETTERS
Volume 23, Issue 17, Pages 1385-1389Publisher
KLUWER ACADEMIC PUBL
DOI: 10.1023/A:1011600414225
Keywords
alginate; galactosylated chitosan; hepatocyte; liver-tissue engineering; sponge
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Porous scaffolds of alginate/galactosylated chitosan (ALG/GC) sponges were prepared by lyophilization for liver-tissue engineering. Primary hepatocytes in ALG/GC sponges showed higher cell attachment and viability than in alginate alone owing to the specific interaction of the asialoglycoprotein receptors on hepatocyte with the galactose residues on ALG/GC sponges. Improvements in spheroid formation and long-term liver-specific functions of the immobilized hepatocyte were also observed in ALG/GC sponge.
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