Journal
JOURNAL OF IMMUNOLOGY
Volume 167, Issue 5, Pages 2671-2676Publisher
AMER ASSOC IMMUNOLOGISTS
DOI: 10.4049/jimmunol.167.5.2671
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- NCI NIH HHS [CA79915, CA09127] Funding Source: Medline
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Interaction of 4-1BB (CD137) and its ligand (4-1BBL) is thought to positively regulate cell-mediated and humoral immune responses. We have prepared transgenic mouse strains that express 4-1BBL cDNA under the control of MHC class II I-E alpha promoter. The 4-1BBL-transgenic mice show progressive splenomegaly and selective depletion of B220(+) B cells accompanied with low levels of circulating IgG and defective humoral responses to Ag challenge. In addition, splenocytes from the transgenic mice fail to provide stimulation for allogeneic T cells in both lymphoproliferative and CTL responses in vitro, whereas their T cells remain functionally normal. Our results reveal unexpected functions of 4-1BBL in the regulation of humoral immune responses and Ag presentation.
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