4.5 Article

Optimization of a screening lead for factor VIIa/TF

Journal

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
Volume 11, Issue 17, Pages 2253-2256

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0960-894X(01)00420-6

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The structure-based design and progression of a screening lead to a 3 nM factor VIIa/TF inhibitor with improved selectivity versus related enzymes is described. (C) 2001 Elsevier Science Ltd. All rights reserved.

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