Journal
JOURNAL OF CHROMATOGRAPHY B
Volume 760, Issue 2, Pages 213-218Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/S0378-4347(01)00270-5
Keywords
venlafaxine; O-desmethylvenlafaxine
Ask authors/readers for more resources
Venlafaxine, a second-generation antidepressant, acts by inhibition of the reuptake of presynaptic noradrenaline and serotonin. The main metabolite, O-desmethylvenlafaxine was found biologically active. For toxicological purpose, a rapid specific and accurate RP-HPLC assay was developed for the simultaneous determination of venlafaxine and O-desmethyl-venlafaxine in human plasma. A linear response was observed over the concentration range 0.2-4 mug/ml. A good accuracy (<8%) was achieved for all quality controls, with intra-day and inter-day variation coefficient less than 10%. Finally, no interference was observed with other psychotic drugs encountered in acute poisoning. This rapid method (run time <10 min) was used to manage four voluntary intoxications involving venlafaxine, (C) 2001 Elsevier Science B.V. All rights reserved.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available