Journal
JOURNAL OF BIOLOGICAL CHEMISTRY
Volume 276, Issue 36, Pages 33576-33581Publisher
AMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
DOI: 10.1074/jbc.M104978200
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Funding
- NCI NIH HHS [CA09673] Funding Source: Medline
- NIAID NIH HHS [AI32489, AI34420] Funding Source: Medline
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A tetrameric, Stat3 complex was found to be essential in transfection experiments for maximal interleukin-6-inducible activation of alpha2-macroglobulin gene promoter. Stable tetramer formation of purified phosphorylated Stat3 was dependent on protein.protein interaction involving the N-terminal domain of Stat3. The functional importance of tetramer formation was shown by the decreased levels of transcriptional activation associated with hypomorphic. mutations in N-terminal residues.
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