Journal
PROCEEDINGS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES
Volume 268, Issue 1478, Pages 1855-1860Publisher
ROYAL SOC
DOI: 10.1098/rspb.2001.1759
Keywords
effective population size; genetic polymorphism; malaria; Plasmodium falciparum
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Funding
- NIGMS NIH HHS [GM34940] Funding Source: Medline
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It has been proposed that the virulent human malaria parasite Plasmodium falciparum underwent a recent severe population bottleneck. In order to test this hypothesis, we estimated the effective population size of this species from the patterns of nucleotide substitution at 23 nuclear protein-coding loci, using a variety of methods based on coalescent theory. Both simple methods and phylogenetically based maximum likelihood methods yielded the conclusion that the effective population size of this species has been of the order of at least 105 for the past 300 000-400 000 years.
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