Journal
SCIENCE
Volume 293, Issue 5536, Pages 1840-1842Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1062882
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In 1997, an H5N1 influenza A virus was transmitted from birds to humans in Hong Kong, killing 6 of the 18 people infected. When mice were infected with the human isolates, two virulence groups became apparent. Using reverse genetics, we showed that a mutation at position 627 in the PB2 protein influenced the outcome of infection in mice. Moreover, high cleavability of the hemagglutinin glycoprotein was an essential requirement for lethal infection.
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