Journal
NEUROLOGY
Volume 57, Issue 5, Pages 895-896Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1212/WNL.57.5.895
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Because nitric oxide (NO) is a putative mediator of oligodendrocyte damage in the primary progressive form of MS (PPMS), the authors analyzed the levels of NO oxidation products in CSF and plasma from 25 patients with PPMS and 15 controls. The levels of nitrite + nitrate (NOx) in CSF were fourfold higher in patients with PPMS than in controls (p < 0.001), whereas the concentrations in plasma were similar. These data suggests involvement of NO in nervous tissue damage in PPMS.
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