Journal
VETERINARY PARASITOLOGY
Volume 100, Issue 1-2, Pages 87-103Publisher
ELSEVIER
DOI: 10.1016/S0304-4017(01)00486-1
Keywords
Leishmania infantum; L. major; leishmaniasis; immune responses; vaccine; dog
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Dogs are the domestic reservoir for Leishmania infantum, the parasite causing zoonotic visceral leishmaniasis (VL) in both the Old and New Worlds. Since the available methods for canine leishmaniasis treatment and control have limited efficacy, the development of a canine Leishmania vaccine is highly desirable. Mechanisms of antileishmanial immune responses in murine, human, and canine infections are briefly presented. Vaccine candidates, including live or killed parasites, Leishmania purified fractions, defined recombinant parasite antigens, live recombinant bacteria expressing Leishmania antigens and antigen-encoding DNA plasmids, are reviewed. Finally, some practical requirements for the evaluation of vaccine candidates in dogs are indicated. (C) 2001 Elsevier Science B.V. All rights reserved.
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