Journal
SCIENCE
Volume 293, Issue 5537, Pages 2087-2092Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1061603
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We have assembled data from Caenorhabditis elegans DNA microarray experiments involving many growth conditions, developmental stages, and varieties of mutants. Co-regulated genes were grouped together and visualized in a three-dimensional expression map that displays correlations of gene expression profiles as distances in two dimensions and gene density in the third dimension. The gene expression map can be used as a gene discovery toot to identify genes that are co-regulated with known sets of genes (such as heat shock, growth control genes, germ line genes, and so forth) or to uncover previously unknown genetic functions (such as genomic instability in mates and sperm caused by specific transposons).
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