Journal
CIRCULATION RESEARCH
Volume 89, Issue 6, Pages 477-479Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1161/hh1801.097034
Keywords
vascular endothelial growth factor; angiopoietin; adhesion; inflammation
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Vascular endothelial growth factor (VEGF) and angiopoietin-1 (Ang1) are potent vasculogenic and angiogenic factors that hold promise as a means to produce therapeutic vascularization and angiogenesis. However, VEGF also acts as a proinflammatory cytokine by inducing adhesion molecules that bind leukocytes; to endothelial cells, an initial and essential step toward inflammation. In the present study, we used human umbilical vascular endothelial cells (HUVECs) to examine the effect of Ang1 on VEGF-induced expression of three adhesion molecules: intercellular adhesion molecule-1 (ICAM-1), vascular cell adhesion molecule-1 (VCAM-1), and E-selectin. Interestingly, Ana1 suppressed VEGF-induced expression of these adhesion molecules. Furthermore, Angl reduced VEGF-induced leukocyte adhesion to HUVECs. These results demonstrate that Ang1 counteracts VEGF-induced inflammation by reducing VEGF-induced endothetial adhesiveness.
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