Journal
NEUROSCIENCE LETTERS
Volume 310, Issue 2-3, Pages 153-156Publisher
ELSEVIER SCI IRELAND LTD
DOI: 10.1016/S0304-3940(01)02116-4
Keywords
transcranial magnetic stimulation; epilepsy; pentylenetetrazol; treatment
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We studied the effects of I ow-frequency repetitive transcranial magnetic stimulation (rTMS) on seizure susceptibility in rats. rTMS of 1000 pulses at 0.5 Hz led to a prolonged latency for seizure development after an intraperitoneal injection of pentylenetetrazol. The rTMS effectively prevented the development of status epilepticus of pentylenetetrazol-induced convulsions. These findings indicate that low-frequency rTMS affects the neural excitability, in the direction of anticonvulsive, and therefore, suggest the possibility of therapeutic use of rTMS in epilepsy. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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