Journal
BIOCHEMICAL JOURNAL
Volume 358, Issue -, Pages 657-664Publisher
PORTLAND PRESS LTD
DOI: 10.1042/bj3580657
Keywords
carbohydrate; intestine; Sd(a)/Cad antigen
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Funding
- NCI NIH HHS [CA 29321] Funding Source: Medline
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This paper describes structural characterization, by NMR, MS and degradative studies of mucin glycans from normal human descending colon obtained freshly at autopsy. The saccharides were mainly based on core 3 (GlcNAc beta1-3GalNAc). Among the terminal saccharide determinants Sd(a)/Cad-antigen-like structures were prominent, and Lewis x, sialyl Lewis x and sulphated Lewis x were found as minor components, whereas blood group H and A antigenic determinants were absent. The saccharides were markedly different from those of mucins from colon cancers or colon cancer cell lines analysed so far, in which cores 1 and 2 are prominent features, and in which various other terminal determinants have been found, but not Sd(a)/Cad.
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