Journal
GENES & DEVELOPMENT
Volume 15, Issue 18, Pages 2361-2366Publisher
COLD SPRING HARBOR LAB PRESS
DOI: 10.1101/gad.206201
Keywords
Slc22a3-Orct3-EMT; Slc22a2-Orct2; Igf2r; genomic imprinting
Categories
Ask authors/readers for more resources
Imprinting of the maternally-expressed Igf2r gene is controlled by an intronic imprint control element (ICE) known as Region2 that contains the promoter of the noncoding Air RNA, whose transcript overlaps the silenced paternal Igf2r promoter in an antisense orientation. Two novel imprinted genes, Slc22a2 and Slc22a3 are described here that lie 110 and 155 kb 3 ' to Igf2r and that are not overlapped by the Air transcript but are regulated by the Igf2r-ICE, as previously shown for Igf2r. These results identify a new cluster of imprinted genes whose repression by the bidirectional action of the Region2-ICE is independent of transcript overlap by the Air RNA.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available