Journal
NEUROREPORT
Volume 12, Issue 13, Pages 2895-2899Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00001756-200109170-00028
Keywords
Alzheimer's disease; hMTHI; mossy fiber synapse; oxidative stress; oxidized purine nucleoside triphosphatase
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The oxidized purine nucleoside triphosphatase, hMTHI, has a critical role towards preventing errors caused by oxidized purine nucleoside triphosphates such as 8-oxo-dGTP and 2-hydroxy-dATP. We investigated the immunohistochemical expression of hMTHI in human hippocampal postmortem tissues representing non-neurological disease and Alzheimer's disease (AD). In the non-neurological subjects the hMTHI protein was enriched in the stratum lucidum at CA3 corresponding to mossy fiber synapses. In AD subjects, the synaptic immunoreactivities at CA3 were significantly decreased, whereas they tended to be increased at the entorhinal cortex. We suggest that the expression of hMTHI indicates indirect evidence of oxidative stress and its regulation is regionally differentiated in AD. NeuroReport 12:2895-2899 (C) 2001 Lippincott Williams & Wilkins.
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