Journal
ORGANIC LETTERS
Volume 3, Issue 19, Pages 3033-3035Publisher
AMER CHEMICAL SOC
DOI: 10.1021/ol010159w
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- NIGMS NIH HHS [GM 44720] Funding Source: Medline
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[GRAPHICS] 1,4-Dien-3-ones bearing pendant arylethyl side chains were readily prepared from substituted dihydrocinnamaldehydes. When treated with TiCl4 at low temperature, these compounds underwent domino cyclization to give benzohydrindenones in near-quantitative yield and with complete diastereoselectivity.
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