Journal
SCIENCE
Volume 293, Issue 5538, Pages 2272-2275Publisher
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1061198
Keywords
-
Categories
Ask authors/readers for more resources
The dendritic arbor of pyramidal neurons is not a monolithic structure. We show here that the excitability of terminal apical, dendrites differs from that of the apical trunk. in response to fluorescence-guided focal photolysis of caged glutamate, individual terminal apical dendrites generated cadmium-sensitive all-or-none responses that were subthreshold for somatic action potentials. Calcium transients produced by all-or-none responses were not restricted to the sites of photolysis, but occurred throughout individual distal dendritic compartments, indicating that electrogenesis is mediated primarily by voltage-gated calcium channels. Compartmentalized and binary behavior of parallel-connected terminal dendrites can greatly expand the computational power of a single neuron.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available