Journal
CHEMICAL COMMUNICATIONS
Volume -, Issue 18, Pages 1710-1711Publisher
ROYAL SOC CHEMISTRY
DOI: 10.1039/b103988c
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The difluoromethylene analogue of aspartyl phosphate 6 has been prepared by the fluoride catalysed coupling of diethyl trimethylsilyldifluoromethyl phosphonate with an appropriate aldehyde followed by Dess-Martin oxidation and deprotection; the deprotected compound inhibited (K-I 95 muM) aspartate semi-aldehyde dehydrogenase, a key enzyme involved in bacterial amino acid and peptidoglycan biosynthesis.
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