Journal
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
Volume 98, Issue 20, Pages 11691-11696Publisher
NATL ACAD SCIENCES
DOI: 10.1073/pnas.191380698
Keywords
-
Categories
Funding
- NEI NIH HHS [EY06979, F32 EY006979, R01 EY000811, R01 EY00811, R01 EY006979] Funding Source: Medline
Ask authors/readers for more resources
Understanding the molecular basis of addiction could be greatly aided by using forward genetic manipulation to lengthen the list of candidate genes involved in this complex process. Here, we report that zebrafish exhibit cocaine-induced conditioned place preference. In a pilot screen of 18 F-2 generation families of mutagenized fish, we found three with abnormally low responses to cocaine. This behavior was inherited by the F-3 generation in a manner that suggests the abnormalities were because of dominant mutations in single genes. Performance profiles in secondary behavioral screens measuring visual dark-adaptation and learning suggest that the defects were the result of mutations in distinct genes that affect dopaminergic signaling in the retina and brain.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available