Journal
AIDS
Volume 15, Issue 14, Pages 1892-1894Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/00002030-200109280-00024
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The CD45 antigen is essential for normal antigen receptor-mediated signalling in lymphocytes, and different patterns of splicing of CD45 are associated with distinct functions in lymphocytes. Here we show that abnormal CD45 splicing caused by a C77G transversion in exon A of the gene encoding CD45 (PTPRC) is associated with increased susceptibility to HIV-1 infection.
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