Journal
PHYTOCHEMISTRY
Volume 58, Issue 4, Pages 599-602Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/S0031-9422(01)00244-8
Keywords
Rhus retinorrhoea; Anacardiaceae; biflavonoids; biflavanone; tetrahydroamentoflavone; antimicrobial activity; antimalarial activity
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The biflavanone (2S,2 S)-7,7 -di-O-methyltetrahydroamentoflavone and five known flavonoids, 7-O-methylnaringenin, 7,3'-O-dimethylquercetin, 7-O-methylapigenin, 7-O-methylluteolin, and eriodictyol were isolated from the leaves of Rhus retinorrhoea Steud, Ex Olive. The biflavanone exhibited moderate antimalarial activity with IC50 0.98 mug/ml against Plasmodium falciparum (W2 Clone) and weak activity against P. falciparum (D6 Clone) with IC50 2.8 mug/ml. Nevertheless, it did not display any cytotoxicity. 7-O-Methylnaringenin showed weak antimicrobial activity against Candida albicans, C. krusei, Staphylococcus aureus, Mycobacterium smegmatis, M. intracellulare, and M. xenopi with MIC similar to 100 mug/ml. Characterization of each compound was based on spectral analysis and comparison with reported data. (C) 2001 Elsevier Science Ltd. All rights reserved.
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