Journal
MECHANISMS OF DEVELOPMENT
Volume 108, Issue 1-2, Pages 45-57Publisher
ELSEVIER
DOI: 10.1016/S0925-4773(01)00471-3
Keywords
angiopoietin; astrocyte; cerebellum; cerebral cortex; differentiation; endothelial cell; flt-1; flk-1; granule cell layer; molecular cell layer; postnatal development; Purkinje cell layer; rat; tie-1; tie-2; vasculature; vascularization; vessel proliferation; vessel regression; VEGF-R1; VEGF-R2; vascular endothelial growth factor
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The vascularization of the central nervous system occurs by angiogenic sprouting, a process in which different factors like vascular endothelial growth factor (VEGF) and angiopoietin (Ang)-1/2 must act in a coordinated fashion. We investigated how these factors participate in capillarization of the cerebellum, an area experiencing marked reorganization processes during its postnatal development. VEGF and Ang-1 mRNA were predominantly expressed by astrocytes, while Ang-2 mRNA was specifically induced at the tip of invading endothelial cell cords. Similar to the cerebral cortex, vascularization of the cerebellum occurred in an inside-out pattern, following closely the generation and differentiation of each cerebellar layer. VEGF and Ang-1/2 expression patterns shifted in a similar inside-out fashion, supporting their proposed function in vessel growth and maturation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.
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